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THCV: “The Skinny Cannabinoid” Succesful in Hemp Extract Weight Loss Trials

South Africa’s cannabis export industry should be embracing the ‘V-factor’ in marijuana compounds, which are increasingly proving effective in weight loss tests. Following Cannabiz Africa’s exclusive story on Pondoland farmers sitting on potentially lucrative landraces high in THCV (tetrahydrocannabivarin) , it’s now emerged that trials in the United States involving a hemp extract which includes THCV and CBDV (cannabidivarin) is also an appetite suppressant.


A take out from a recent Cannabiz Africa interview with M. Ayanda Bam – Co-Founder of Friends of Hemp South Africa.


THCV & Weight Loss: the “skinny cannabinoid”

THCV, like other cannabinoids, acts on the body’s endocannabinoid system, which helps maintain physiological, cognitive and emotional stability. Research has shown that THCV can act as an effective appetite suppressant, earning it the nickname the “skinny cannabinoid.” Other studies have shown that THCV can also help regulate blood sugar levels. THCV has also been shown to have anti-inflammatory and anti-seizure properties.

Now it’s emerged that THCV can be extracted from hemp.  According to human trials involving a double-blind, placebo-controlled study of Nitro-V hemp, all 100 participants who took the extract shed up to 10 kg over a 90-day period. Of the control group that was fed the placebo , 64% either gained weight or saw no change.

The study subjects taking the hemp extract, which is rich in CBD, THCV, CBDV and other cannabinoids, also showed improvements in other metabolic health metrics and key wellness indicators – without changing their diet and exercise habits. Participants taking Nitro-V saw their body mass index (BMI) scores drop by an average of three points and lost an average of 1,1 cm from their waist measurements. On average, study subjects in the placebo group gained weight and saw their BMI remain the same.

Each softgel microcapsule serving of Nitro-V contains 50mg of hemp extract with a combination of cannabinoids including CBD, THCV and CBDV in a base of organic hemp seed oil. The solventless hemp extract contains the complete cannabinoid profile found in the source plant, including less than 0.1% THC. Further processing boosts levels of THCV and CBDV in the supplement.


THCV research paving the way for cannabis diet pills

Researchers are obviously eyeing the weight loss market. An estimated 73% of US adults 20 and older in the United States are overweight or obese, risking heart disease, diabetes and high blood pressure. Further research shows that between 2013 and 2016, more than 49% of American adults reported trying to lose weight. 

“Those working to reduce their weight and enhance their overall health are looking for any advantage they can find to help them stick to their exercise and nutrition regimens,” Arthur Jaffee, CEO of Nitro-V manufacturer ECS Brands, said in a press release on 2 August 2021. “With the results of these studies, we think that Nitro-V could be the tool to help many unlock their weight-loss potential and feel better.”

Jaffee noted that recent research found that CBD and THCV can affect lipid and glucose metabolism in animals, both important factors for maintaining a healthy weight. The study also found that CBD had multiple beneficial effects on hyperglycemia, mainly due to its anti-inflammatory and antioxidant properties. Additional evidence from animal studies shows that CBD modulates cardiovascular response to stress, which plays a role in weight gain and loss. The connection between CBDV and weight loss, however, is “less direct,” he says.

“Research shows that CBDV is a powerful anti-inflammatory, which can play a role in both appetite and weight. Reduced inflammation in the body helps optimize performance of metabolic organs and fat cells themselves are metabolic organs. Inflamed fat cells don’t function properly, and can contribute toward unhealthy weight gain.”

The Nitro-V study also revealed several other changes in the participants’ health and wellness, including many with the potential to affect weight loss. Participants using the supplement in the research showed a 61% reduction in hunger and had less frequent food cravings. Additionally, all 37 subjects taking Nitro-V who were classified as prediabetic saw their blood sugar levels return to normal at the end of the 90-day study. Subjects also reported less difficulty resisting food cravings and showed improvements in sleep, happiness and anxiety levels. The research also showed the hemp extract to be well tolerated and safe, with blood work revealing that all safety and toxicity levels remained within healthy, normal ranges.

While the study was designed to investigate the effect that Nitro-V can have on weight loss, Jaffee says that the data indicates the supplement may have other health and wellness benefits as well.

“The ultimate goal of the study was to identify the overarching power of the ECS system, and the results point towards effects beyond weight loss and appetite suppression,” he writes. “But as with all cannabinoid and ECS researchers today, we still have many unanswered questions about how interactions between cannabinoids and the ECS lead to health improvements.”

One Response

  1. THCV, is a psychoactive cannabinoid compound with a variety of remarkable effects and medical benefits. As research on THCV progresses, its’ full potential becomes more fascinating. This cannabinoid has been known to leave its’ consumers feeling

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